How to Say "Sciatic Nerve" in Japanese

坐骨神経

zakotsushinkei[d͡za̠ko̞t͡sɨɕĩŋke̞ː]

The English phrase 'sciatic nerve' is translated into Japanese as 坐骨神経 (zakotsushinkei).

坐骨神経 is the term used to refer to the large nerve. In casual conversation, many Japanese people will simply say 腰の神経.

Meaning: large nerve (noun)

How do you pronounce it?

zakotsushinkei

While 坐骨神経 is the clinical name, Japanese speakers often describe the sharp sensation of nerve pain using the onomatopoeia ピリピリ, which mimics the sound of something sizzling or tingling.
The word 神経 used in the phrase can also be used to describe a person's temperament, such as calling someone 神経質 to mean they are 'neurotic' or 'fussy'.
In a medical setting, you will see the kanji 坐 for 'sit', but in almost every other context, Japanese people use the more common kanji 座.

坐骨神経が痛いです。
zakotsu shinkei ga itai desu.
My sciatic nerve hurts.
坐骨神経痛の症状があります。
zakotsu shinkei tsuu no shoujou ga arimasu.
I have symptoms of sciatica.
坐骨神経を圧迫しているようです。
zakotsu shinkei o appaku shite iru you desu.
It seems like the sciatic nerve is being compressed.

Yota tells Misaki about his leg pain.

陽太 Yota

最近、足にひどい痛みがあるんだ。
saikin, ashi ni hidoi itami ga aru nda.
Recently, I've had severe pain in my leg.
美咲 Misaki

それは坐骨神経の問題じゃない？
sore wa zakotsu shinkei no mondai janai?
Could it be a problem with your sciatic nerve?
陽太 Yota

明日、病院で診てもらうつもりだよ。
ashita, byōin de mite morau tsumori da yo.
I plan to have a doctor look at it tomorrow.
美咲 Misaki

お大事にね、陽太さん。
o-daiji ni ne, Yōta-san.
Take care of yourself, Yota.

Sources

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